Seoochre

Cancer is considered as a common name to address a large group comprising more than 100 diseases affecting several parts of the body. All cancers show common characteristics such as the uncontrolled growth and proliferation of abnormal cells, infiltrating and spreading to different tissues and organs throughout the body, and destroying the normal cells and tissues. Cancer can begin in the epithelial tissue and is known as carcinomas, and when it begins in the connective or supportive tissue, they are called sarcomas. The blood cancers are known as leukemias, and when it begins in the plasma c

This article explores the profound impact of bioinformatics in the realm of precision oncology, revolutionising the understanding, diagnosis, and treatment of cancer. Bioinformatics, a multidisciplinary field, bridges the gap between vast biological datasets and meaningful insights, enabling personalised therapies and groundbreaking discoveries. However, challenges in data integrity, reproducibility, and infrastructure must be overcome to fully realise it’s potential. Bioinformatics stands as a beacon of hope, ushering in an era where cancer is decoded at its molecular core, promising improve

While traditional vaccine modalities continue to play an important role, 87% of the respondents intend to focus on mRNA and the majority believe this modality will dominate the future vaccine landscape. Most manufacturers stated an intent to establish capabilities in novel vaccine platforms and indicated that both traditional and modern cell-based vaccines remain important given their proven regulatory record, high efficacy, and generally fewer side effects.

Given the protection offered by the SARS-CoV-2 mRNA vaccines and the accelerated development timelines, it’s no surprise that this mo

A countless number of proteins including growth factors receptors, and cytokines play a pivotal role during the onset and exacerbation of numerous human diseases including cancer, autoimmune and inflammatory disorders.1

Of these proteins, extracellular and membrane-associated proteins represent around 40% of human proteome and they play diversified roles including signal transduction, cell adhesion, cell-cell interaction, and solute transport. Accordingly, the vast majority (ca. 60%) of current therapeutic approaches; such as small molecule inhibitors, oligonucleotide agents and monoclonal

Many Pharma companies in EU suffer a size problem. When revenues are below 100 M€ is extremely difficult to survive in a market where to renew the portfolio is increasingly costly, as well as to pay the regulatory demands, which grow year by year (environmental regulations, verification, wastes processing, plastics control, etc...). Additionally, the easy solution of playing in the Generics Market does not work anymore, mostly due to the devastating price erosion in major markets (France, Germany, Italy and Spain). These companies use to be a family property and their operations do not exceed

Human and veterinary antimicrobial misuse is one of the cornerstone drivers of antimicrobial resistance (AMR) leading to a rapidly drying up of the antibiotic pipeline. In 2010, the Indian subcontinent was adjudicated to be the world’s largest consumer of antibiotics and hence curbing injudicious use of antibiotics was a must. The current drivers of AMR include veterinary, human, biomedical waste and from innate evolutionary genetical factors leading to the genesis of the menacing MDR, XDR and PDR strains seen worldwide. High grade of evidence now underscores the necessity for antimicrobial s

Menarini Biomarkers (A. Menarini Biomarkers Singapore Pte Ltd) was founded with the mission of identifying, developing, and validating new biomarkers on circulating human cells for applications in diagnostics.

There is a current healthcare gap in precision medicine surrounding the fields of early disease prediction and disease control, particularly related to precision rare-cell isolation, analysis, and disease diagnosis. Menarini Biomarkers uses single-cell analysis to provide clinicians with new tools for early detection, tracking disease progression, and the measurement of real-time res

Precision drugs need to be defined and validated as having the molecular structure that would interact with a precisely defined disease target. Further, it must exhibit the right pharmacokinetics to facilitate the drugs’ efficacy. Ideally, onand off-target interactions should not cause disabling adverse events.

Precision drugs are yet to be discovered and developed. Drug discovery often starts with a “shot in the dark.” A huge number of compounds are often “filtered” in silico before being examined using high throughput screening to identify potentially relevant active compounds that are s

In our constantly changing world, healthcare is an essential element of growth. Pursuing safer, more effective healthcare solutions has led to innovative strategies transforming the industry.

Clinical trials and Contract Research Organisations (CROs) play essential roles in these transformative methods. Let's explore these approaches and understand how they contribute to making healthcare safer and more effective.

Technological advancements, evolving patient expectations, and the need for proven, evidence-based therapies collectively drive substantial changes in the healthcare sector. T

A radiopharmaceutical is a radioactive compound used for the diagnosis and treatment of human diseases. In nuclear medicine, nearly 95% of the radiopharmaceuticals are used for diagnostic purposes, while the rest are used for treatment. It is a relatively new modality to develop a new way for cell biology, and molecular biology is also the new definition for diagnostic imaging. Radiolabelling and imaging are making light on the pharmaceutical field just because the substance has a particular mechanism of localisation for the foreign particles and no need for the complicated structural require

The European pharmaceutical market is a complex and multifaceted landscape shaped by a diverse regulatory framework, regional variations, and key industry players. Comprising a network of countries with distinct healthcare systems and regulatory authorities, the European market demands a nuanced understanding from pharmaceutical companies. The regulatory framework is governed by the European Medicines Agency (EMA), which coordinates the evaluation and supervision of medicines across member states. Beyond the centralized approach, individual countries retain authority over pricing, reimburseme

In the realm of sustainable manufacturing practices, pharmaceutical companies are demonstrating a growing commitment to green chemistry principles. This strategic shift underscores a conscious effort to prioritize environmentally friendly raw materials and processes throughout the drug manufacturing lifecycle. By opting for greener alternatives, companies aim to reduce the ecological impact of their operations while promoting responsible resource utilization.

Specific examples abound of innovative applications of green chemistry in drug manufacturing, with success stories highlighting the

In its initial phases, European pharmaceutical firms started acknowledging the possibilities for growth beyond their conventional geographic boundaries. The recognition that global expansion could open up new markets, encourage international collaborations, and optimize operational costs prompted a strategic reorientation. This article explores the opportunities and challenges stemming from the globalization of pharmaceutical operations for European companies, tracing the historical trajectory that has shaped the current interconnected and dynamic pharmaceutical landscape.

By exploring the

The pharmaceutical sector encounters intricate data security challenges in its IT setup, encompassing data sensitivity, regulatory compliance, cybersecurity threats, supply chain risks, and insider threats. Addressing these issues necessitates implementing strong access controls, adhering to compliance standards, employing cybersecurity protocols, scrutinizing the supply chain, and providing comprehensive employee training. To ensure operational integrity and safeguard sensitive information, a continual commitment to adaptation, collaboration, and investment in advanced technologies is indisp

The article explores the transformative impact of telehealth on pharmaceutical distribution strategies. It delves into challenges such as logistics and regulatory compliance, presenting opportunities like direct-to-patient models and technology integration. Emphasizing patient safety and compliance, it advocates for strategic partnerships, patient-centric approaches, data analytics, and stakeholder education. Innovation, particularly through blockchain and IoT, is highlighted, along with the importance of a global perspective. The conclusion underscores the need for adaptability and continuou

Blockchain technology is increasingly recognized as a transformative force in healthcare, particularly in enhancing clinical trials and data integrity. Its applications range from automated smart contracts 1 improving research quality, to permissioned blockchain frameworks 234 ensuring robust data security. Innovations like BlockTrial 5 and Scrybe 6 utilize platforms such as Ethereum for tamper-resistant data management and compliance. The technology also extends to patient consent management 7, health information exchange 8, and virtual clinical trials 9, advocating for decentralized, patien

Entering the North American pharmaceutical market demands a comprehensive strategy. Understanding FDA regulations, conducting thorough market analysis, building strategic partnerships, adapting to healthcare trends, implementing effective market access strategies, and utilizing digital marketing are key components. Prioritizing risk mitigation, ensuring compliance, and developing contingency plans further enhance the likelihood of sustainable success in this dynamic industry.The FDA assumes a crucial role in upholding public health by exercising rigorous control over pharmaceuticals in the Un

Artificial Intelligence (AI) and Machine Learning (ML) are fundamentally reshaping the landscape of drug discovery, emerging as pivotal game-changers. These transformative technologies excel in analyzing vast datasets, encompassing genomic, chemical, and clinical information, and identifying intricate patterns that elude traditional methods. Their capacity to predict potential drug candidates with remarkable efficiency accelerates the drug development process, significantly reducing the time and resources required for discovery. Pioneering companies such as Atomwise and BenevolentAI leverage

Cannabis plants contain a wide variety of complex compounds including phytocannabinoids, terpenoids and flavonoids, found mainly in the inflorescences. Major phytocannabinoids like CBD and ∆9-THC have beneficial effects on human health. It is well known that variations in their profiles are connected to growth, light quality, humidity, the use of pesticides, harvesting and especially post-harvesting, like improper drying procedures that can facilitate fungal and microbial growth. Mass spectrometry is the tool of choice for the analysis of all these biologically active compounds along with tha

The spleen is an organ found in all vertebrates. It is a large secondary lymphoid organ that primarily functions as a blood filter. The second spleen’s function is immune system surveillance. As a specialized immune organ, the spleen plays a significant role in innate and adaptive immunity. Specifically, the spleen is a crucial organ for peripheral immune tolerance, complementing central immune tolerance. Splenectomy in both study animals and humans results in overwhelming infections with especially, encapsulated bacteria [1]. On the opposite, supporting the immune system with an additional s